We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Bactericidal activity of two different dosage regimens of imipenem in an in-vitro dynamic model.
- Authors
Maggiolo, Franco; Taras, Alberto; Frontespezi, Stefano; Bottari, Francesco; Legnani, Maria Cristina; Suter, Fredy; Maggiolo, F; Taras, A; Frontespezi, S; Bottari, F; Legnani, M C; Suter, F
- Abstract
The antimicrobial activity of imipenem was tested in an in-vitro model mimicking human serum pharmacokinetics after either 1000 mg im once daily or 500 mg im twice daily. Six recent clinical isolates of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae and Salmonella group B were used as test strains. Our results suggest that a single daily dose of imipenem 1000 mg im exerts an antibacterial action comparable to that obtained with two divided doses of 500 mg.
- Subjects
BIOLOGICAL models; COMPARATIVE studies; DRUG administration; DOSE-effect relationship in pharmacology; DYNAMICS; INTRAMUSCULAR injections; RESEARCH methodology; MEDICAL cooperation; MICROBIAL sensitivity tests; RESEARCH; EVALUATION research; IMIPENEM; PHARMACODYNAMICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1993, Vol 32, Issue 2, p295
- ISSN
0305-7453
- Publication type
journal article