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- Title
Absorption of oral ofloxacin after cytotoxic chemotherapy for haematological malignancy.
- Authors
Brown, N. M.; White, L. O.; Blundell, E. L.; Chown, S. R.; Slade, R. R.; MacGowan, A. P.; Reeves, D. S.
- Abstract
Ten patients with newly diagnosed haematological malignancy were given ofloxacin, 400 mg daily orally, for antibacterial prophylaxis during neutropenia. Before cyto-toxic chemotherapy was given, and on three occasions between days 2–3, 5–7 and 8–10 afterwards, blood samples were taken before and 1, 2, 3, 4, 6 and 10 h after administration of ofloxacin. Serum ofloxacin concentrations were measured by HPLC. Mean (range) pharmacokinetic parameters before chemotherapy were: , 6·1 (2·7–9·1) mg/L; AUC, 7·5 (1·9–11·6) mg.h/L. On days 2–3 post-chemotherapy the values were reduced to: C, 5·0 (3·6–7·3) mg/L; AUC, 5·8 (1·9–7·8) mg.h/L. On days 5–7 the values were: C, 6·1 (4·0–10·4) mg/L; AUC, 8·5 (0·8–16·8) mg.h/L, and by days 8–10 the values were: C, 6·4 (3·3–12·5) mg/L; AUC, 8·6 (0·8–23·1) mg.h/L. There was a statistically significant difference between C pre- and C two to three days post-chemotherapy (paired -test, = 0·05). These changes are similar to those previously reported with ciprofloxacin but less marked.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1993, Vol 32, Issue 1, p117
- ISSN
0305-7453
- Publication type
journal article