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- Title
Synthesis and Butyllithium-Induced Cyclisation of 2-Benzyloxyphenylphosphonamidates Giving 2,3-Dihydrobenzo[ d ][1,3]oxaphospholes.
- Authors
Aitken, R. Alan; Ait Moulay, Khadija; Cordes, David B.; Inwood, Ryan A.; Jamieson, Fraser G.; Nelson, Alexander J. B.; McKay, Aidan P.
- Abstract
A series of fourteen O-ethyl-N-butylphenylphosphonamidates with benzyl ether substituents at the ortho position was prepared and fully characterised. Upon treatment with n-butyllithium in THF at RT, they underwent cyclisation in eight cases to give the novel 2,3-dihydrobenzo[d][1,3]oxaphospholes in moderate to low yield as a single diastereomer, for which the relative configuration was determined by X-ray diffraction in one case.
- Subjects
BUTYLLITHIUM; ORGANIC synthesis; SUBSTITUENTS (Chemistry); BENZYL ethers; RING formation (Chemistry)
- Publication
Organics, 2024, Vol 5, Issue 1, p12
- ISSN
2673-401X
- Publication type
Article
- DOI
10.3390/org5010002