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- Title
Metabolic interactions of agrochemicals in humans.
- Authors
Hodgson, Ernest; Rose, Randy L.
- Abstract
The article discusses the metabolic interactions of agrochemicals based on inhibition, induction and/or cytotoxicity in humans. It is noted that agrochemicals and other xenobiotics are metabolized by xenobiotic-metabolizing enzymes (XMEs) to products more or less toxic than parent chemicals. The study shows that these interactions can be demonstrated through human liver microsomes, recombinant human enzymes or human hepatocytes. It was discovered that their potency varies, though some effects occur at very low substrate concentrations. This suggests that the groundwork has been laid for studies involving microarray techniques and genotyping of exposed individuals with particular toxic endpoints.
- Subjects
AGRICULTURAL chemicals; ENZYME inhibitors; TOXICOLOGICAL interactions; BIOCHEMICAL toxicology; ENZYMES; ENZYMOLOGY; XENOBIOTICS; METABOLISM; HUMAN beings
- Publication
Pest Management Science, 2008, Vol 64, Issue 6, p617
- ISSN
1526-498X
- Publication type
Article
- DOI
10.1002/ps.1563