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- Title
Eicosanoid storm in infection and inflammation.
- Authors
Dennis, Edward A.; Norris, Paul C.
- Abstract
Controlled immune responses to infection and injury involve complex molecular signalling networks with coordinated and often opposing actions. Eicosanoids and related bioactive lipid mediators derived from polyunsaturated fatty acids constitute a major bioactive lipid network that is among the most complex and challenging pathways to map in a physiological context. Eicosanoid signalling, similar to cytokine signalling and inflammasome formation, has primarily been viewed as a pro-inflammatory component of the innate immune response; however, recent advances in lipidomics have helped to elucidate unique eicosanoids and related docosanoids with anti-inflammatory and pro-resolution functions. This has advanced our overall understanding of the inflammatory response and its therapeutic implications. The induction of a pro-inflammatory and anti-inflammatory eicosanoid storm through the activation of inflammatory receptors by infectious agents is reviewed here.
- Subjects
EICOSANOIDS; IMMUNE response; UNSATURATED fatty acids; LEUKOTRIENES; DOCOSAHEXAENOIC acid; MASS spectrometry
- Publication
Nature Reviews Immunology, 2015, Vol 15, Issue 8, p511
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri3859