We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Modulation of the immune system by UV radiation: more than just the effects of vitamin D?
- Authors
Hart, Prue H.; Gorman, Shelley; Finlay-Jones, John J.
- Abstract
Humans obtain most of their vitamin D through the exposure of skin to sunlight. The immunoregulatory properties of vitamin D have been demonstrated in studies showing that vitamin D deficiency is associated with poor immune function and increased disease susceptibility. The benefits of moderate ultraviolet (UV) radiation exposure and the positive latitude gradients observed for some immune-mediated diseases may therefore reflect the activities of UV-induced vitamin D. Alternatively, other mediators that are induced by UV radiation may be more important for UV-mediated immunomodulation. Here, we compare and contrast the effects of UV radiation and vitamin D on immune function in immunopathological diseases, such as psoriasis, multiple sclerosis and asthma, and during infection.
- Subjects
IMMUNE system; ULTRAVIOLET radiation; PHYSIOLOGICAL effects of vitamin D; VITAMIN D deficiency; DISEASE susceptibility; IMMUNOREGULATION
- Publication
Nature Reviews Immunology, 2011, Vol 11, Issue 9, p584
- ISSN
1474-1733
- Publication type
journal article
- DOI
10.1038/nri3045