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- Title
Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system?
- Authors
Reizis, Boris; Colonna, Marco; Trinchieri, Giorgio; Barrat, Franck; Gilliet, Michel
- Abstract
Plasmacytoid dendritic cells (pDCs) were first described as interferon-producing cells and, for many years, their overlapping characteristics with both lymphocytes and classical dendritic cells (cDCs) created confusion over their exact ontogeny. In this Viewpoint article, Nature Reviews Immunology asks five leaders in the field to discuss their thoughts on the development and functions of pDCs--do these cells serve mainly as a major source of type I interferons or do they also make other important contributions to immune responses?
- Subjects
DENDRITIC cells; LYMPHOCYTES; INTERFERONS; ONTOGENY; CYTOKINES; IMMUNE system; CYTOLOGICAL research
- Publication
Nature Reviews Immunology, 2011, Vol 11, Issue 8, p558
- ISSN
1474-1733
- Publication type
review
- DOI
10.1038/nri3027