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- Title
The functional plasticity of T cell subsets.
- Authors
Bluestone, Jeffrey A.; Mackay, Charles R.; O'Shea, John J.; Stockinger, Brigitta
- Abstract
In 1986, Robert Coffman and Timothy Mossman first described the division of CD4(+) T cells into functional subsets, termed T helper 1 (T(H)1) and T(H)2, based on cytokine production, and in doing so unwittingly opened a Pandora's box of complexity and controversy. Although the mechanisms that regulate T(H)1 and T(H)2 cells are now well known, recent descriptions of other CD4(+) T cell subsets--such as regulatory T cells, T follicular helper cells, T(H)17, T(H)22 and most recently T(H)9 and T(H)22 cells--have questioned how we think of T cell subsets and what commitment to a functional T cell subset means. Here, Nature Reviews Immunology asks four leaders in the field their thoughts on the functional plasticity of T cell subsets.
- Subjects
CYTOKINES; CD4 antigen; TH1 cells; TH2 cells; CELL division; CELLULAR mechanics; MATERIAL plasticity
- Publication
Nature Reviews Immunology, 2009, Vol 9, Issue 11, p811
- ISSN
1474-1733
- Publication type
research
- DOI
10.1038/nri2654