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- Title
Tumor Suppressive Effects of GAS5 in Cancer Cells.
- Authors
Kaur, Jesminder; Salehen, Nur'ain; Norazit, Anwar; Rahman, Amirah Abdul; Murad, Nor Azian Abdul; Rahman, Nik Mohd Afizan Nik Abd.; Ibrahim, Kamariah
- Abstract
In recent years, long non-coding RNAs (lncRNAs) have been shown to play important regulatory roles in cellular processes. Growth arrests specific transcript 5 (GAS5) is a lncRNA that is highly expressed during the cell cycle arrest phase but is downregulated in actively growing cells. Growth arrests specific transcript 5 was discovered to be downregulated in several cancers, primarily solid tumors, and it is known as a tumor suppressor gene that regulates cell proliferation, invasion, migration, and apoptosis via multiple molecular mechanisms. Furthermore, GAS5 polymorphism was found to affect GAS5 expression and functionality in a cell-specific manner. This review article focuses on GAS5's tumor-suppressive effects in regulating oncogenic signaling pathways, cell cycle, apoptosis, tumor-associated genes, and treatment-resistant cells. We also discussed genetic polymorphisms of GAS5 and their association with cancer susceptibility.
- Subjects
GROWTH arrest-specific 5; LINCRNA; CANCER cells; CANCER susceptibility; GENETIC polymorphisms; CELL cycle
- Publication
Non-Coding RNA, 2022, Vol 8, Issue 3, p39
- ISSN
2311-553X
- Publication type
Article
- DOI
10.3390/ncrna8030039