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- Title
ATG16L1 T300A polymorphism and Crohn’s disease susceptibility: evidence from 13,022 cases and 17,532 controls.
- Authors
Hai-Feng Zhang; Li-Xin Qiu; Yu Chen; Wa-Li Zhu; Chen Mao; Li-Guang Zhu; Ming-Hua Zheng; Yan Wang; Lei Lei; Jian Shi
- Abstract
Many studies have reported the association between the autophagy-related 16-like 1 gene ( ATG16L1) T300A polymorphism (rs2241880) and Crohn’s disease (CD) susceptibility, but the results were inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 24 studies including 13,022 cases and 17,532 controls were included in this meta-analysis. Logistic regression analysis indicated that the ATG16L1 T300A polymorphism was associated with CD risk in Caucasians ( P < 0.01). The pooled estimations of OR1 (GG vs. AA) and OR2 (GA vs. AA) in Caucasian studies by Bayesian meta-analysis method was [1.87, 95% confidence interval (CI) 1.69–2.05] and (1.39, 95% CI 1.27–1.51), respectively. The mode of heritance of the G allele was most likely to be co-dominant in Caucasians. However, no significant association was found in Asians. This meta-analysis suggests that the G allele of ATG16L1 T300A is a low-penetrant gene for developing CD in Caucasians.
- Subjects
CROHN'S disease; GENETIC polymorphisms; META-analysis; CAUCASIAN race; LOGISTIC regression analysis
- Publication
Human Genetics, 2009, Vol 125, Issue 5/6, p627
- ISSN
0340-6717
- Publication type
Article
- DOI
10.1007/s00439-009-0660-7