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- Title
Aktueller Stand der Labordiagnostik einer HIV-Infektion.
- Authors
Weber, T.; Hunsmann, G.
- Abstract
The cumulative incidence for HlV-infection is 647.2. cases per million for the United States. In Germany it is only 71.3 per million. Using redundant screening tests the risk of transmitting HIV by blood transfusion can be reduced to less than 1 in WO 000. Sensitivity and specificity of commercial ELISAs are at least 99%. Simple screening tests such as the latex agglutination and the gelatme agglutination assay use recombinant antigens or synthetic peptides and permit the screening of a large number of samples in a short time. Positive reactions are confirmed by Immunoblot (Western Blot) or radioimmuno precipitation assay (RIPA). By recombinant antigen ELISA HIV- infections can be distinguished from HIV-2 infections. Virus culture and detection of viral DNA and RNA by polymerase chain reaction (PCR) are increasingly used for diagnostic purposes. The demonstration of a rising p24 antigen, the decrease of CD4+ cells as well as the increase of beta-2-microglobulin, neopterin, interleukin-6 and soluble interleukin 2 receptor signify an unfavorable prognosis.
- Publication
Journal of Laboratory Medicine / Laboratoriums Medizin, 1991, Vol 15, Issue 12, p613
- ISSN
0342-3026
- Publication type
Article