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- Title
Serologically indicated pneumococcal pneumonia in children: a population-based study in primary care settings.
- Authors
HEISKANEN-KOSMA, TARJA; KORPPI, MATTI; LEINONEN, MAIJA
- Abstract
Heiskanen-Kosma T, Korppi M, Leinonen M. Serologically indicated pneumococcal pneumonia in children: a population-based study in primary care settings. APMIS 2003;111:945–50. The aim of the study was to assess age-specific incidences of community-acquired pneumonia (CAP) caused by Streptococcus pneumoniae and diagnosed serologically in a child population. The study was population-based, and prospective, and performed in primary health care settings. During a surveillance period of 12 months from 1981–1982, all pneumonia cases in a defined child population (57% urban residents) were registered prospectively. In total, 201 CAP cases were diagnosed (mean age 5.6 years; 57% boys; 58% urban residents). S. pneumoniae etiology was studied by antibody and immune complex (IC) assays to C-polysacchride (C-PS), type-specific capsular polysaccharides (CPS), and to pneumolysin (Ply), in acute and convalescent sera. Serologic evidence of S. pneumoniae etiology was indicated in 57(28%) cases, 35(61%) being mixed infections with other microbes. The distribution of pneumococcal cases was 44%, 30% and 26% in the three 5-year age groups, respectively. There were 33 (58%) males and 34 (60%) urban residents. In total, 26 cases were identified by antibody assays and 35 cases by IC assays, 26/35 being positive in acute sera. Responses to C-PS, CPS and Ply, when antibody and IC results are combined, were found equally often in 23–25 cases. The total annual incidence of pediatric S. pneumoniae CAP was 6.4/1000/year. S. pneumoniae etiology was found in 28% of the children and was similar at all ages. The incidence of pneumococcal CAP was assessed for the first time, being high (19/1000/year) in 0- to 4-year-old urban boys and rather stable (5–9/1000/year) in all other groups by age, sex and residence.
- Subjects
PNEUMOCOCCAL pneumonia; STREPTOCOCCAL diseases; LUNG infections; JUVENILE diseases; PRIMARY care
- Publication
APMIS, 2003, Vol 111, Issue 10, p945
- ISSN
0903-4641
- Publication type
Article
- DOI
10.1034/j.1600-0463.2003.1111005.x