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- Title
A T-helper cell epitope overlaps a major B-cell epitope in human papillomavirus type 18 E2 protein.
- Authors
LEHTINEN, MATTI; STELLATO, GIOVANNI; HYÖTY, HEIKKI; NIEMINEN, PEKKA; VESTERINEN, ERVO; PAAVONEN, JORMA
- Abstract
Cultivated CD4+ T-helper cells from two patients with cervical adenocarcinoma showed responses to a peptide EKTGILTVTYHSETQRTK derived from an E2 protein of human papillomavirus type 18 (HPV 18), but not to a corresponding HPV 16 peptide (HKSAIVTLTYDSEWQRDQ). Serum antibodies in the HPV 18 peptide were also demonstrated in these patients. The GILT motif resembles a common pattern present in many T-cell epitopes, and is located at the beginning of an 11-amino acid-long A-helix structure close to the carboxyterminal end of HPV 18 E2. We conclude that two epitopes (a T-helper cell epitope and a B-cell epitope) overlap in the HPV 18 E2.
- Publication
APMIS, 1992, Vol 100, Issue 7-12, p1022
- ISSN
0903-4641
- Publication type
Article
- DOI
10.1111/j.1699-0463.1992.tb04035.x