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- Title
下丘脑弓状核PYY对大鼠摄食、胃运动和能量代谢的影响及机制.
- Authors
薛秀菊; 聂文波; 冷慧; 王茜; 孙向荣; 郭菲菲; 徐珞
- Abstract
Objetive: To investigate the effects and potential mechanisms of YY peptide (PYY) on the feeding, gastric motility and energy metabolism in male Wistar rats. Methods: The expression of Y2 receptor in the arcuate nucleus (PYY) of rat hypothalamus was observed by immunohistochemistry. The expression of metabolic hormone mRNA in the hypothalamus and the PYY response in ARC were observed by microinjection of PYY into ARC. Sexual neuron discharge frequency, rat food intake and water intake, oxygen consumption (VO2), CO2 production (VCO2) and energy metabolism. Results: Immunohistochemistry showed that Y2 receptor was present in rat ARC; PYY in rats with ARC could stimulate PYY-reactive neurons; ARC microinjection of PYY could up-regulate the expression of anti-peptide peptides such as (cocaine amphetamine-regulated transcript) CART and (corticotropin releasing hormone) CRH, and down-regulate Neuropeptide Y (NPY) and hypocretin (HCRT). The expression of the peptide peptide mRNA; and PYY can participate in the regulation of changes in rat respiration, energy metabolism and gastric motility. Conclusion: ARC microinjection of PYY can reduce food intake and regulate systemic energy balance. PYY may be a new metabolic peptide in rats.
- Subjects
CORTICOTROPIN releasing hormone; DRINKING (Physiology); NEUROPEPTIDE Y; ENERGY metabolism; GASTROINTESTINAL motility
- Publication
Progress in Modern Biomedicine, 2019, Vol 19, Issue 21, p4020
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2019.21.005