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- Title
伊伐布雷定对慢性心力衰竭患者血浆桥接整合因子1 含量的影响.
- Authors
邹卓璇; 邱英茹; 陈浩; 张东霞; 李舒; 刘凤岐; 张瑞英
- Abstract
Objective: To discuss the effect of ivabradine on the plasma level of bridging integrator 1 (Bin1) in patients with chronic heart failure (CHF). Methods:40 cases of CHF patients with left ventricular ejection fraction (LVEF) <40% and 23 healthy people were enrolled in this study. CHF patients were divided into the ivabradine group (n=20) and conventional therapy group (n=20). The concentration of Bin1 and N-terminal pro-brain natriuretic peptide (NT-proBNP), the changes of cardiac function related parameters were measured and compared between different groups. After 30 days of treatment, all the above-mentioned index were measured in the ivabradine group and conventional therapy group again. Results: Compared with the healthy control group, the concentration of plasma Bin1 was significantly decreased in the CHF group (1248.84± 238.04 pg/mL vs. 1047.85± 304.82 pg/mL, P<0.05). The concentration of plasma Bin1 in the CHF group was positively correlated with the LVEF (r=0.567, P<0.05), and negatively correlated with the LVEDd (r =-0.332, P<0.05) and NT-proBNP (r=-0.509, P<0.05). After treatment with ivbradine, the concentration of Bin1 was increased by (△ 234.98± 267.18 pg/mL). While after conventional therapy, the concentration of Bin1 was only increased by (△ 34.87± 66.89 pg/mL). There was significant difference in the changes of Bin1 concentrations between the ivbradine and conventional therapy groups (P<0.05). Conclusion: The level of Bin1 in CHF patients was significantly decreased and was positively correlated with cardiac function. Ivabradine could increase the plasma level of Bin1 in patients with CHF, it is beneficial to improve the cardiac excitation-contraction coupling and increase the myocardial contraction.
- Subjects
BRAIN natriuretic factor; CARDIAC contraction; GROUP psychotherapy; VENTRICULAR ejection fraction; HEART failure patients; IVABRADINE
- Publication
Progress in Modern Biomedicine, 2019, Vol 19, Issue 15, p2915
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2019.15.026