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- Title
丙种球蛋白联合地屈孕酮治疗复发性流产的效果及对患者免疫功能 和血清炎症因子水平的影响
- Authors
邰迎春; 赵爱妮; 王晶; 赵丽华; 孙丽娜
- Abstract
Objectiv: To investigate the effect of gamma globulin combined with megestrol acetate in the treatment of recurrent spontaneous abortion and its influence on immune function and serum inflammatory factors. Methods: 82 patients with recurrent spontaneous abortion admitted to our hospital from January 2016 to December 2017 were randomly divided into two groups. The control group was treated with oral megestrol acetate only, and the observation group was given intravenous gamma globulin [500 mg/ (kg d)] on the basis of the control group. The serum levels of IL-6, TNF-αand IL-10, CD4+/CD8+, CD8+, CD4+, and the success rate of pregnancy preservation were compared between the two groups. Results: After treatment, 14 cases were cured, 18 cases were effective and 9 cases were ineffective in the observation group. The effective rate was 78.05%(32/41), which was significantly higher than that in the control group [60.98% (25/41)](P<0.05). And the levels of serum TNF-αand CD8+ in the two groups were significantly lower than those before treatment (P<0.05), the levels of serum IL-6, IL-10, CD4+/CD8+ and CD4+ were significantly higher than those before treatment (P<0.05). The levels of serum TNF-αand CD8+ in the observation group were significantly lower than those in the control group (P<0.05). The levels of serum IL-6, IL-10, CD4+/CD8+ and CD4+ in the observation group were significantly higher than those in the control group (P<0.05). The success rate of the observation group was 82.93%(34/41), which was significantly higher than that of the control group [31.71% (13/41)] (P<0.05). Conclusion: Gamma globulin combined with megestrol acetate can effectively enhance the immune function of patients with recurrent spontaneous abortion, reduce the expression of inflammatory factors, and improve the success rate of pregnancy preservation.
- Subjects
MISCARRIAGE; GAMMA globulins; IMMUNE system; CYTOKINES; INFLAMMATION; THERAPEUTIC use of progestational hormones; SYNTHETIC progestagens
- Publication
Progress in Modern Biomedicine, 2019, Vol 19, Issue 11, p2112
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2019.11.023