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- Title
天香胶囊对晕动病模型大鼠行为学与前庭核c-fos蛋白表达的影响.
- Authors
张凡; 李卫红; 李峰; 刘燕; 于雪; 王旭; 高誉珊; 胡艳红; 张炜悦; 孙天石; 张楚焌; 董一昕
- Abstract
Objective: To investigate the effects of Tianxiang capsule on the behavior and c-los expression in the vestibule nucleus of rats with motion sickness. Methods: Male SD rats were randomly divided into six groups, including normal group, model group, scopolamine group, low-dose, mid-dose and high-dose Tianxiang capsule groups. Prior to biaxial rotation stimulus inducing rats motion sickness model, the drugs were intragastrically administrated for 3 days. The behavioral changes of rats were evaluated by the motion sickness index, the spontaneous activity test and Kaolin pica. Meanwhile, the expression of c-los was detected by Western Blotting and Immunohistochemistty. Results: Compared with the normal group, the motion sickness index and Kaolin intake were increased, total traveling distance and frequency were decreased, the c-fos expression was up-regulated significantly in the model group. Compared with the model group, the motion sickness index and Kaolin intake were decreased, total traveling distance and frequency were increased, the c-fos expression was down-regulated significantly in Tianxiang capsule groups. Conclusions: Tianxiang capsule could effectively im- prove the behavioral changes of rats with motion sickness, which might be related to the down-regulation of c-fos in vestibular nucleus. Inhibiting the excitability of vestibular nucleus may be the pharmacological mechanisms of Tianxiang capsule in motion sickness.
- Publication
Progress in Modern Biomedicine, 2018, Vol 18, Issue 5, p807
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2018.05.002