We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Meta-Analysis of the Association between a Polymorphism in MicroRNA-196a2 and Susceptibility to Colorectal Cancer.
- Authors
Shi, Ke-Qing; Lin, Zhuo; Li, De-Wei; Fang, Yu-Xiao; Gao, Jian; Deng, Zhu-Jun; Chen, Li; Li, Gui-Ling; Wu, Jian-Min; Tang, Kai-Fu
- Abstract
Background/Aims: To accurately evaluate the impact of the C/T polymorphism in microRNA (miRNA)-196a2 on the colorectal cancer (CRC) risk, by meta-analysis. Methods: An electronic search for articles was conducted in PubMed, EMBASE, ISI Web of Science, and the Cochrane Library. The pooled odds ratio (OR) and its 95% confidence interval (CI) were used to assess the association through meta-analysis. Results: 5 studies were used for analysis. The results showed a significant association between the miRNA-196a2 C/T polymorphism and CRC risk in the genetic models (C vs. T: OR = 1.168, 95% CI = 1.106-1.282, p = 0.001; CC vs. TT: OR = 1.368, 95% CI = 1.132-1.654, p = 0.001; TC/CC vs. TT: OR = 1.206, 95% = CI 1.035-1.405, p = 0.016; CC vs. TC/TT: OR = 1.254, 95% CI = 1.077-1.461, p = 0.004), with the exception of the TC-versus-TT model (TC vs. TT: OR = 1.130, 95% CI = 0.961-1.329, p = 0.138). In a subgroup analysis based on ethnicity, we identified a significant overrepresentation of the polymorphism in individuals of Asian ethnicity. Conclusion: This meta-analysis indicates a significant association between the miRNA-196a2 polymorphism and CRC risk.
- Publication
Oncology Research & Treatment, 2013, Vol 36, Issue 10, p560
- ISSN
2296-5270
- Publication type
Article
- DOI
10.1159/000355158