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- Title
Metabolic syndrome and its components are associated with increased chronic kidney disease risk: Evidence from a meta-analysis on 11 109 003 participants from 66 studies.
- Authors
Alizadeh, Shahab; Ahmadi, Mahsa; Ghorbani Nejad, Behnam; Djazayeri, Abolghassem; Shab‐Bidar, Sakineh; Shab-Bidar, Sakineh
- Abstract
<bold>Background& Aims: </bold>Observational studies examining the relationship between metabolic syndrome and the risk of chronic kidney disease (CKD) have reported inconclusive results. This meta-analysis was performed to resolve these controversies.<bold>Methods: </bold>The MEDLINE, EMBASE, and PubMed databases were systematically searched from their inception until March 2016 to identify all relevant studies. Risk estimates and their corresponding 95% confidence intervals (CIs) for the associations of MetS and its components with CKD risk were extracted and pooled using a random-effects model.<bold>Results: </bold>A total of 66 studies, including 18 prospective cohorts and 48 cross-sectional studies, with 699 065 CKD patients and 11 109 003 participants were included in the meta-analysis. When all definitions were pooled, the presence of MetS was associated with a significant 50% increase of CKD risk (OR = 1.50, 95% CI = 1.43-1.56), with evidence of moderate heterogeneity (I2 = 72.3%, P < .001). The risk of CKD associated with MetS was higher in studies using the American Heart Association/National Heart, Lung, and Blood Institute criteria (OR = 1.68, 95% CI = 1.25-2.10) compared with those using the Adult Treatment Panel III (OR = 1.49, 95% CI = 1.42-1.56) and the International Diabetes Federation (OR = 1.32, 95% CI = 1.22-1.41) definitions. This relationship was independent of diabetes status. Moreover, all individual components of the MetS were significantly associated with CKD, and their coexistence resulted in an escalating dose-response relationship. The sensitivity and subgroup analyses established the stability of the findings.<bold>Conclusions: </bold>This meta-analysis strongly suggests that the metabolic syndrome and its components are independently associated with the increased risk of CKD.
- Publication
International Journal of Clinical Practice, 2018, Vol 72, Issue 8, p1
- ISSN
1368-5031
- Publication type
journal article
- DOI
10.1111/ijcp.13201