We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A Rare Case of Hyponatremia Caused by Reset Osmostat in a Neonate with Cleft Lip, Cleft Palate, and Imperforate Anus.
- Authors
Jung Gu Ahn; Jeong Eun Lee; Woo Yeong Chung; Soo Hyun Koo; Jaeho Shin; Ga Won Jeon
- Abstract
Hyponatremia is defined as a plasma sodium concentration of <135 mEq/L. It is a common electrolyte imbalance in newborns. We report the case of a term neonate with cleft lip, cleft palate, imperforate anus, normal male karyotype, and chronic hyponatremia. On the 4th day of life, he showed hyponatremia (plasma sodium concentration 130 mEq/L) with low serum osmolality (275 mOsm/kg), high urine sodium (116.7 mEq/L), and high urine osmolality (412 mOsm/kg). His thyroid and adrenal functions were normal. Despite intravenous and oral sodium supplementation and hydrocortisone treatment, hyponatremia persisted. Brain magnetic resonance imaging showed normal results. He was diagnosed as having reset osmostat, a rare subtype of the syndrome of inappropriate secretion of antidiuretic hormone characterized by a subnormal threshold for antidiuretic hormone secretion, with hypotonic hyponatremia.
- Subjects
HYPONATREMIA; CLEFT lip; CLEFT palate; IMPERFORATE anus; NEONATAL diseases
- Publication
Neonatal Medicine, 2018, Vol 25, Issue 3, p131
- ISSN
2287-9412
- Publication type
Article
- DOI
10.5385/nm.2018.25.3.131