We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Fyn, a Potential Target for Alzheimer's Disease.
- Authors
Yang, Kai; Belrose, Jillian; Trepanier, Catherine H.; Lei, Gang; Jackson, Michael F.; MacDonald, John F.
- Abstract
Alzheimer's disease (AD) is the most common form of dementia characterized by the presence of amyloid-β (Aβ) plaques and neurofibrillary tangles. The mechanisms leading to AD are not completely understood; however, recent evidence suggests that alterations in Fyn, a Src family kinase, might contribute to AD pathogenesis. A number of studies have demonstrated that Fyn is involved in synaptic plasticity, a cellular mechanism for learning and memory. In addition, Fyn plays a role in the regulation of Aβ production and mediates Aβ-induced synaptic deficits and neurotoxicity. Fyn also induces tyrosine phosphorylation of tau. Although many studies have implicated a role for Fyn in AD, the precise cellular and molecular mechanisms require further investigation. Novel insights into the role of Fyn in AD may help identify alternative pharmacological approaches for the treatment of AD.
- Subjects
ALZHEIMER'S disease research; AMYLOID beta-protein; PROTEIN kinases; SYNAPSES; NEUROTOXICOLOGY
- Publication
Journal of Alzheimer's Disease, 2011, Vol 27, Issue 2, p243
- ISSN
1387-2877
- Publication type
Article
- DOI
10.3233/JAD-2011-110353