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- Title
Amyloid-β₄₂ is associated with cognitive impairment in healthy elderly and subjective cognitive impairment.
- Authors
Rolstad S; Berg AI; Bjerke M; Blennow K; Johansson B; Zetterberg H; Wallin A; Rolstad, Sindre; Berg, Anne Ingeborg; Bjerke, Maria; Blennow, Kaj; Johansson, Boo; Zetterberg, Henrik; Wallin, Anders
- Abstract
The aim of this study was to predict cognitive performance on the basis of the cerebrospinal fluid (CSF) biomarkers total tau (T-tau) and amyloid-β₄₂ (Aβ₄₂) in controls and patients at various impairment levels. Previous studies have found an association of CSF T-tau levels with cognitive symptoms, but it has been difficult to relate Aβ to cognition, and it has thus been hypothesized that Aβ reaches a plateau level prior to cognitive symptoms. A comprehensive battery of neuropsychological tests was subjected to factor analysis to yield aggregated cognitive domains. Linear regression models were performed for the total sample of the Gothenburg MCI study (n = 435) and for each level of impairment. Aβ₄₂ and T-tau accounted for a significant proportion of performance in all cognitive domains in the total sample. In controls (n = 60) and patients with subjective cognitive impairment (n = 105), Aβ₄₂ predicted a significant proportion of semantic and working memory performance. For patients with mild cognitive impairment (n = 170), T-tau had the most pronounced impact across cognitive domains, and more specifically on episodic memory, visuospatial, and speed/executive performance. For patients with dementia (n = 100), the most pronounced impacts of Aβ₄₂ were found in episodic memory and visuospatial functioning, while T-tau was substantially associated with episodic memory. Our results suggest that cognition is related to CSF biomarkers regardless of impairment level. Aβ₄₂ is associated with cognitive functions from a potentially early to a later disease phase, and T-tau is more indicative of performance in a later disease phase.
- Subjects
COGNITION disorders diagnosis; COGNITION; COGNITION disorders; NEUROPSYCHOLOGICAL tests; NERVE tissue proteins; PEPTIDES; PSYCHOLOGICAL tests; REGRESSION analysis; SHORT-term memory; THOUGHT &; thinking; VISUAL perception
- Publication
Journal of Alzheimer's Disease, 2011, Vol 23, Issue 1, p135
- ISSN
1387-2877
- Publication type
journal article
- DOI
10.3233/JAD-2011-110038