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- Title
IL-1β Antibody Protects Brain from Neuropathology of Hypoperfusion.
- Authors
Quintana, Dominic; Ren, Xuefang; Hu, Heng; Corbin, Deborah; Engler-Chiurazzi, Elizabeth; Alvi, Muhammad; Simpkins, James; Jin, Kunlin; Su, Huanxing; Yang, Guo-Yuan
- Abstract
Chronic brain hypoperfusion is the primary cause of vascular dementia and has been implicated in the development of white matter disease and lacunar infarcts. Cerebral hypoperfusion leads to a chronic state of brain inflammation with immune cell activation and production of pro-inflammatory cytokines, including IL-1β. In the present study, we induced chronic, progressive brain hypoperfusion in mice using ameroid constrictor, arterial stenosis (ACAS) surgery and tested the efficacy of an IL-1β antibody on the resulting brain damage. We observed that ACAS surgery causes a reduction in cerebral blood flow (CBF) of about 30% and grey and white matter damage in and around the hippocampus. The IL-1β antibody treatment did not significantly affect CBF but largely eliminated grey matter damage and reduced white matter damage caused by ACAS surgery. Over the course of hypoperfusion/injury, grip strength, coordination, and memory-related behavior were not significantly affected by ACAS surgery or antibody treatment. We conclude that antibody neutralization of IL-1β is protective from the brain damage caused by chronic, progressive brain hypoperfusion.
- Subjects
LEUKOENCEPHALOPATHIES; NEUROLOGICAL disorders; CEREBRAL circulation; ENCEPHALITIS; VASCULAR dementia; PERFUSION
- Publication
Cells (2073-4409), 2021, Vol 10, Issue 4, p855
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells10040855