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- Title
Nuclear Inositides and Inositide-Dependent Signaling Pathways in Myelodysplastic Syndromes.
- Authors
Xian, Jie; Owusu Obeng, Eric; Ratti, Stefano; Rusciano, Isabella; Marvi, Maria Vittoria; Fazio, Antonietta; De Stefano, Alessia; Mongiorgi, Sara; Cappellini, Alessandra; Ramazzotti, Giulia; Manzoli, Lucia; Cocco, Lucio; Follo, Matilde Yung
- Abstract
Myelodysplastic syndromes (MDS) are a heterogeneous group of hematological malignancies characterized by peripheral blood cytopenia and abnormal myeloproliferation, as well as a variable risk of evolution into acute myeloid leukemia (AML). The nucleus is a highly organized organelle with several distinct domains where nuclear inositides localize to mediate essential cellular events. Nuclear inositides play a critical role in the modulation of erythropoiesis or myelopoiesis. Here, we briefly review the nuclear structure, the localization of inositides and their metabolic enzymes in subnuclear compartments, and the molecular aspects of nuclear inositides in MDS.
- Subjects
MYELODYSPLASTIC syndromes; ACUTE myeloid leukemia; HEMATOLOGIC malignancies; NUCLEAR structure
- Publication
Cells (2073-4409), 2020, Vol 9, Issue 3, p697
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells9030697