We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Risk of hospitalization with sodium‐glucose cotransporter‐2 inhibitors versus dipeptidyl peptidase‐4 inhibitors in patients with type 2 diabetes lacking evidence of chronic kidney disease: Real‐world data.
- Authors
Schechter, Meir; Melzer Cohen, Cheli; Zelter, Tamir; Yanuv, Ilan; Rozenberg, Aliza; Chodick, Gabriel; Karasik, Avraham; Mosenzon, Ofri
- Abstract
Following propensity-score matching, there were 6477 patients in each arm; 5431 patients (41.9%) were women and the mean (SD) patient age was 59.8 (10.9) years (Table 1). Patients with T2D, who initiated an SGLT2 inhibitor (empagliflozin or dapagliflozin) in an outpatient setting between August 2015 and December 2020 were propensity-scored matched with patients starting a DPP-4 inhibitor (sitagliptin, linagliptin, vildagliptin or saxagliptin). Risk of hospitalization with sodium-glucose cotransporter-2 inhibitors versus dipeptidyl peptidase-4 inhibitors in patients with type 2 diabetes lacking evidence of chronic kidney disease: Real-world data Patients with type 2 diabetes (T2D) have a high incidence of hospitalizations that reduce patients' quality of life and are translated into a significant burden on healthcare systems, accompanied by increased costs.[[1]] Randomized controlled trials (RCTs) showed that sodium-glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of cardiovascular events, heart failure (HF) hospitalizations, and kidney outcomes in patients with T2D, HF, or chronic kidney disease (CKD).[3] In some of these RCTs, SGLT2 inhibitors also modestly reduced the risk for any hospitalization.[[4], [6], [8], [10]] However, these studies included patients with T2D and high cardiovascular risk,[[4], [6], [11]] or patients with CKD with and without T2D.[[8]] Whether SGLT2 inhibitor use is associated with a lower risk for any hospitalization in a general population of patients with T2D, especially patients without CKD, is unknown.
- Subjects
SODIUM-glucose cotransporters; TYPE 2 diabetes; CD26 antigen; CHRONIC kidney failure; GESTATIONAL diabetes; HOSPITAL care; SYSTOLIC blood pressure
- Publication
Diabetes, Obesity & Metabolism, 2023, Vol 25, Issue 10, p3054
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/dom.15172