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Effects of insulin and oral anti-diabetic agents on glucose metabolism, vascular dysfunction and skeletal muscle inflammation in type 2 diabetic subjects.
Published in:
Diabetes/Metabolism Research & Reviews, 2011, v. 27, n. 4, p. 373, doi. 10.1002/dmrr.1185
By:
- Joya-Galeana, J.;
- Fernandez, M.;
- Cervera, A.;
- Reyna, S.;
- Ghosh, S.;
- Triplitt, C.;
- Musi, N.;
- DeFronzo, R. A.;
- Cersosimo, E.
Publication type:
Article
Impaired regulation of the TNF-α converting enzyme/tissue inhibitor of metalloproteinase 3 proteolytic system in skeletal muscle of obese type 2 diabetic patients: a new mechanism of insulin resistance in humans.
Published in:
Diabetologia, 2009, v. 52, n. 10, p. 2169, doi. 10.1007/s00125-009-1451-3
By:
- Monroy, A.;
- Kamath, S.;
- Chavez, A.;
- Centonze, V.;
- Veerasamy, M.;
- Barrentine, A.;
- Wewer, J.;
- Coletta, D.;
- Jenkinson, C.;
- Jhingan, R.;
- Smokler, D.;
- Reyna, S.;
- Musi, N.;
- Khokka, R.;
- Federici, M.;
- Tripathy, D.;
- DeFronzo, R.;
- Folli, F.
Publication type:
Article
Mitochondrial reactive oxygen species generation in obese non-diabetic and type 2 diabetic participants.
Published in:
Diabetologia, 2009, v. 52, n. 4, p. 574, doi. 10.1007/s00125-009-1264-4
By:
- Abdul-Ghani, M.;
- Jani, R.;
- Chavez, A.;
- Molina-Carrion, M.;
- Tripathy, D.;
- DeFronzo, R.
Publication type:
Article
Pioglitazone stimulates AMP-activated protein kinase signalling and increases the expression of genes involved in adiponectin signalling, mitochondrial function and fat oxidation in human skeletal muscle in vivo: a randomised trial.
Published in:
Diabetologia, 2009, v. 52, n. 4, p. 723, doi. 10.1007/s00125-008-1256-9
By:
- Coletta, D.;
- Sriwijitkamol, A.;
- Wajcberg, E.;
- Tantiwong, P.;
- Li, M.;
- Prentki, M.;
- Madiraju, M.;
- Jenkinson, C.;
- Cersosimo, E.;
- Musi, N.;
- DeFronzo, R.
Publication type:
Article
Effects of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ agonists on glucose and lipid metabolism in patients with type 2 diabetes mellitus.
Published in:
Diabetologia, 2007, v. 50, n. 8, p. 1723, doi. 10.1007/s00125-007-0698-9
By:
- Bajaj, M.;
- Suraamornkul, S.;
- Hardies, L.;
- Glass, L.;
- Musi, N.;
- DeFronzo, R.
Publication type:
Article
Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans.
Published in:
Diabetologia, 2006, v. 49, n. 10, p. 2317, doi. 10.1007/s00125-006-0384-3
By:
- Richardson, D. K.;
- Schneider, J.;
- Fourcaudot, M. J.;
- Rodriguez, L. M.;
- Arya, R.;
- Dyer, T. D.;
- Almasy, L.;
- Blangero, J.;
- Stern, M. P.;
- DeFronzo, R. A.;
- Duggirala, R.;
- Jenkinson, C. P.
Publication type:
Article
To: Godsland IF, Jeffs JA, Johnston DG (2004) Loss of beta cell function as fasting glucose increases in the non-diabetic range. Diabetologia 47:1157–1166.
Published in:
2005
By:
- Abdul-Ghani, M. A.;
- DeFronzo, R. A.
Publication type:
Letter
Reply to Comment on: Gastaldelli A, Ferrannini E, Miyazaki Y, Matsuda M, DeFronzo RA (2004) Beta cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study. Diabetologia 43:31-39.
Published in:
2004
By:
- Gastaldelli, A.;
- Ferrannini, E.;
- Miyazaki, Y.;
- Matsuda, M.;
- DeFronzo, R.
Publication type:
Letter
Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes Adiponectin receptors and insulin sensitivity.
Published in:
Diabetologia, 2004, v. 47, n. 5, p. 816, doi. 10.1007/s00125-004-1359-x
By:
- Civitarese, A. E.;
- Jenkinson, C. P.;
- Richardson, D.;
- Bajaj, M.;
- Cusi, K.;
- Kashyap, S.;
- Berria, R.;
- Belfort, R.;
- DeFronzo, R. A.;
- Mandarino, L. J.;
- Ravussin, E.
Publication type:
Article
Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study A. Gastaldelli et al.: Beta -cell dysfunction and glucose intolerance.
Published in:
Diabetologia, 2004, v. 47, n. 1, p. 31, doi. 10.1007/s00125-003-1263-9
By:
- Gastaldelli, A.;
- Ferrannini, E.;
- Miyazaki, Y.;
- Matsuda, M.;
- DeFronzo, R. A.
Publication type:
Article
Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance E. Ferrannini et al.: Beta-cell function in IGT.
Published in:
Diabetologia, 2003, v. 46, n. 9, p. 1211, doi. 10.1007/s00125-003-1169-6
By:
- Ferrannini, E.;
- Gastaldelli, A.;
- Miyazaki, Y.;
- Matsuda, M.;
- Pettiti, M.;
- Natali, A.;
- Mari, A.;
- DeFronzo, R. A.
Publication type:
Article
Effect of rosiglitazone on glucose and non-esterified fatty acid metabolism in Type II diabetic patients.
Published in:
Diabetologia, 2001, v. 44, n. 12, p. 2210, doi. 10.1007/s001250100031
By:
- Miyazaki, Y.;
- Glass, L.;
- Triplitt, C.;
- Matsuda, M.;
- Cusi, K.;
- Mahankali, A.;
- Mahankali, S.;
- Mandarino, L. J.;
- DeFronzo, R. A.
Publication type:
Article
NIA0002 Novel role for adiponectin pathway in human skeletal muscle bioenergetics.
Published in:
Obesity Reviews, 2006, v. 7, p. 37, doi. 10.1111/j.1467-7881.2006.00280_8.x
By:
- Civitarese, A. E.;
- Nawrocki, A. R.;
- Ukropcova, B.;
- Carling, S.;
- Hulver, M.;
- DeFronzo, R. A.;
- Mandarino, L.;
- Scherer, P.;
- Smith, S. R.;
- Ravussin, E.
Publication type:
Article
EFFECTS OF ACUTE EXERCISE AND TRAINING ON INSULIN BINDING TO MONOCYTES AND INSULIN SENSITIVITY IN VIVO.
Published in:
Acta Paediatrica, 1980, v. 69, n. S283, p. 70, doi. 10.1111/j.1651-2227.1980.tb15319.x
By:
- KOIVISTO, V. A.;
- SOMAN, V. R.;
- DEFRONZO, R.;
- FELIG, P.
Publication type:
Article
Dysfunctional fat cells, lipotoxicity and type 2 diabetes.
Published in:
International Journal of Clinical Practice (Supplement), 2004, v. 58, p. 9, doi. 10.1111/j.1368-504X.2004.00389.x
By:
- Defronzo, R. A.
Publication type:
Article
Insulin Secretion Predicts the Response to Antidiabetic Therapy in Patients With New-onset Diabetes.
Published in:
2021
By:
- Abdelgani, S.;
- Puckett, C.;
- Adams, J.;
- Triplitt, C.;
- DeFronzo, R. A.;
- Abdul-Ghani, M.
Publication type:
journal article
The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia.
Published in:
Diabetes, Obesity & Metabolism, 2012, v. 14, n. 1, p. 5, doi. 10.1111/j.1463-1326.2011.01511.x
By:
- DeFronzo, R. A.;
- Davidson, J. A.;
- Del Prato, S.
Publication type:
Article
Metabolic effects of muraglitazar in type 2 diabetic subjects.
Published in:
Diabetes, Obesity & Metabolism, 2011, v. 13, n. 10, p. 893, doi. 10.1111/j.1463-1326.2011.01429.x
By:
- Fernandez, M.;
- Gastaldelli, A.;
- Triplitt, C.;
- Hardies, J.;
- Casolaro, A.;
- Petz, R.;
- Tantiwong, P.;
- Musi, N.;
- Cersosimo, E.;
- Ferrannini, E.;
- DeFronzo, R. A.
Publication type:
Article
High-density lipoprotein-cholesterol and not HbA1c was directly related to cardiovascular outcome in PROactive.
Published in:
Diabetes, Obesity & Metabolism, 2011, v. 13, n. 8, p. 759, doi. 10.1111/j.1463-1326.2011.01404.x
By:
- Ferrannini, E.;
- Betteridge, D. J.;
- Dormandy, J. A.;
- Charbonnel, B.;
- Wilcox, R. G.;
- Spanheimer, R.;
- Erdmann, E.;
- DeFronzo, R. A.;
- Laakso, M.
Publication type:
Article
Rosiglitazone and pioglitazone similarly improve insulin sensitivity and secretion, glucose tolerance and adipocytokines in type 2 diabetic patients.
Published in:
Diabetes, Obesity & Metabolism, 2008, v. 10, n. 12, p. 1204, doi. 10.1111/j.1463-1326.2008.00880.x
By:
- Miyazaki, Y.;
- DeFronzo, R. A.
Publication type:
Article
Effect of misoprostol (PGE1) on glucose metabolism in type-2-diabetic and control subjects.
Published in:
Diabetes, Obesity & Metabolism, 2002, v. 4, n. 3, p. 195, doi. 10.1046/j.1463-1326.2002.00203.x
By:
- Lee, N;
- Matsuda, M;
- Bressler, P;
- Pratipanawatr, T;
- Glass, L;
- Mandarino, L;
- DeFronzo, R
Publication type:
Article
Impaired renal tubular potassium secretion in sickle cell disease.
Published in:
1979
By:
- DeFronzo, Ralph A.;
- Taufield, Phyllis August;
- Black, Henry;
- McPhedran, Peter;
- Cooke, C. Robert;
- DeFronzo, R A;
- Taufield, P A;
- Black, H;
- McPhedran, P;
- Cooke, C R
Publication type:
journal article
Effect of Exenatide on Splanchnic and Peripheral Glucose Metabolism in Type 2 Diabetic Subjects.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2011, v. 96, n. 6, p. 1763, doi. 10.1210/jc.2010-2146
By:
- Cersosimo, E.;
- Gastaldelli, A.;
- Cervera, A.;
- Wajcberg, E.;
- Sriwijilkamol, A.;
- Fernandez, M.;
- Zuo, P.;
- Petz, R.;
- Triplitt, C.;
- Musi, N.;
- DeFronzo, R. A.
Publication type:
Article
Lentivirus shRNA Grb10 targeting the pancreas induces apoptosis and improved glucose tolerance due to decreased plasma glucagon levels.
Published in:
Diabetologia, 2012, v. 55, n. 3, p. 719, doi. 10.1007/s00125-011-2414-z
By:
- Doiron, B.;
- Hu, W.;
- Norton, L.;
- DeFronzo, R.
Publication type:
Article
Chromatin occupancy of transcription factor 7-like 2 (TCF7L2) and its role in hepatic glucose metabolism.
Published in:
Diabetologia, 2011, v. 54, n. 12, p. 3132, doi. 10.1007/s00125-011-2289-z
By:
- Norton, L.;
- Fourcaudot, M.;
- Abdul-Ghani, M.;
- Winnier, D.;
- Mehta, F.;
- Jenkinson, C.;
- DeFronzo, R.
Publication type:
Article
Erratum to: Is the ADA/EASD algorithm for the management of type 2 diabetes (January 2009) based on evidence or opinion? A critical analysis.
Published in:
2010
By:
- Schernthaner, G.;
- Barnett, A.;
- Betteridge, D.;
- Carmena, R.;
- Ceriello, A.;
- Charbonnel, B.;
- Hanefeld, M.;
- Lehmann, R.;
- Malecki, M.;
- Nesto, R.;
- Pirags, V.;
- Scheen, A.;
- Seufert, J.;
- Sjöholm, Å.;
- Tsatsoulis, A.;
- DeFronzo, R.
Publication type:
Correction Notice
Is the ADA/EASD algorithm for the management of type 2 diabetes (January 2009) based on evidence or opinion? A critical analysis.
Published in:
2010
By:
- Schernthaner, G.;
- Barnett, A.;
- Betteridge, D.;
- Carmena, R.;
- Ceriello, A.;
- Charbonnel, B.;
- Hanefeld, M.;
- Lehmann, R.;
- Malecki, M.;
- Nesto, R.;
- Pirags, V.;
- Scheen, A.;
- Seufert, J.;
- Sjohölm, A.;
- Tsatsoulis, A.;
- DeFronzo, R.
Publication type:
Editorial
Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009.
Published in:
Diabetologia, 2010, v. 53, n. 7, p. 1270, doi. 10.1007/s00125-010-1684-1
By:
- DeFronzo, R.
Publication type:
Article
Determinants of glucose tolerance in impaired glucose tolerance at baseline in the Actos Now for Prevention of Diabetes (ACT NOW) study.
Published in:
Diabetologia, 2010, v. 53, n. 3, p. 435, doi. 10.1007/s00125-009-1614-2
By:
- DeFronzo, R.;
- Banerji, M.;
- Bray, G.;
- Buchanan, T.;
- Clement, S.;
- Henry, R.;
- Kitabchi, A.;
- Mudaliar, S.;
- Musi, N.;
- Ratner, R.;
- Reaven, P.;
- Schwenke, D.;
- Stentz, F.;
- Tripathy, D.
Publication type:
Article
The effect of muraglitazar on adiponectin signalling, mitochondrial function and fat oxidation genes in human skeletal muscle in vivo.
Published in:
Diabetic Medicine, 2015, v. 32, n. 5, p. 657, doi. 10.1111/dme.12664
By:
- Coletta, D. K.;
- Fernandez, M.;
- Cersosimo, E.;
- Gastaldelli, A.;
- Musi, N.;
- DeFronzo, R. A.
Publication type:
Article
Relationship of baseline HbA<sub>1c</sub> and efficacy of current glucose-lowering therapies: a meta-analysis of randomized clinical trials.
Published in:
Diabetic Medicine, 2010, v. 27, n. 3, p. 309, doi. 10.1111/j.1464-5491.2010.02941.x
By:
- DeFronzo, R. A.;
- Stonehouse, A. H.;
- Han, J.;
- Wintle, M. E.
Publication type:
Article
Strong association between insulin resistance in liver and skeletal muscle in non-diabetic subjects.
Published in:
Diabetic Medicine, 2008, v. 25, n. 11, p. 1289, doi. 10.1111/j.1464-5491.2008.02597.x
By:
- Abdul-Ghani, M. A.;
- Matsuda, M.;
- DeFronzo, R. A.
Publication type:
Article
Revitalization of pioglitazone: the optimum agent to be combined with a sodium-glucose co-transporter-2 inhibitor.
Published in:
Diabetes, Obesity & Metabolism, 2016, v. 18, n. 5, p. 454, doi. 10.1111/dom.12652
By:
- DeFronzo, R. A.;
- Chilton, R.;
- Norton, L.;
- Clarke, G.;
- Ryder, R. E. J.;
- Abdul‐Ghani, M.
Publication type:
Article
Initial combination therapy with metformin, pioglitazone and exenatide is more effective than sequential add-on therapy in subjects with new-onset diabetes. Results from the Efficacy and Durability of Initial Combination Therapy for Type 2 Diabetes ( EDICT): a randomized trial
Published in:
Diabetes, Obesity & Metabolism, 2015, v. 17, n. 3, p. 268, doi. 10.1111/dom.12417
By:
- Abdul‐Ghani, M. A.;
- Puckett, C.;
- Triplitt, C.;
- Maggs, D.;
- Adams, J.;
- Cersosimo, E.;
- DeFronzo, R. A
Publication type:
Article
Effect of pioglitazone on body composition and bone density in subjects with prediabetes in the ACT NOW trial.
Published in:
Diabetes, Obesity & Metabolism, 2013, v. 15, n. 10, p. 931, doi. 10.1111/dom.12099
By:
- Bray, G. A.;
- Smith, S. R.;
- Banerji, M. A.;
- Tripathy, D.;
- Clement, S. C.;
- Buchanan, T. A.;
- Henry, R. R.;
- Kitabchi, A. E.;
- Mudaliar, S.;
- Musi, N.;
- Ratner, R. E.;
- Schwenke, D. C.;
- Stentz, F. B.;
- Reaven, P. D.;
- DeFronzo, R. A.
Publication type:
Article
Impaired renal tubular potassium secretion in systemic lupus erythematosus.
Published in:
1977
By:
- DeFronzo, R A;
- Cooke, C R;
- Goldberg, M;
- Cox, M;
- Myers, A R;
- Agus, Z S
Publication type:
journal article
Normal diluting capacity in hyponatremic patients. Reset osmostat or a variant of the syndrome of inappropriate antidiuretic hormone secretion.
Published in:
1976
By:
- DeFronzo, R A;
- Goldberg, M;
- Agus, Z S
Publication type:
journal article
Renal transplantation in multiple myeloma. A case report.
Published in:
1975
By:
- Humphrey, R L;
- Wright, J R;
- Zachary, J B;
- Sterioff, S;
- DeFronzo, R A
Publication type:
journal article
Reduction in Hematocrit and Hemoglobin Following Pioglitazone Treatment is not Hemodilutional in Type II Diabetes Mellitus.
Published in:
Clinical Pharmacology & Therapeutics, 2007, v. 82, n. 3, p. 275, doi. 10.1038/sj.clpt.6100146
By:
- Berria, R.;
- Glass, L.;
- Mahankali, A.;
- Miyazaki, Y.;
- Monroy, A.;
- De Filippis, E.;
- Cusi, K.;
- Cersosimo, E.;
- DeFronzo, R. A.;
- Gastaldelli, A.
Publication type:
Article
Vanadyl Sulfate Improves Hepatic and Muscle Insulin Sensitivity in Type 2 Diabetes.
Published in:
Journal of Clinical Endocrinology & Metabolism, 2001, v. 86, n. 3, p. 1410, doi. 10.1210/jc.86.3.1410
By:
- CUSI, K.;
- CUKIER, S.;
- DEFRONZO, R. A.;
- TORRES, M.;
- PUCHULU, F. M.;
- PEREIRA REDONDO, J. C.
Publication type:
Article
Improved insulin sensitivity in patients with type I diabetes mellitus after CSII.
Published in:
1985
By:
- Simonson, D C;
- Tamborlane, W V;
- Sherwin, R S;
- Smith, J D;
- DeFronzo, R A
Publication type:
journal article
The disposal of an oral glucose load in healthy subjects. A quantitative study.
Published in:
1985
By:
- Ferrannini, Eleuterio;
- Bjorkman, Ola;
- Reichard Jr., George A.;
- Pilo, Alessandro;
- Olsson, Maggie;
- Wahren, John;
- DeFronzo, Ralph A.;
- Ferrannini, E;
- Bjorkman, O;
- Reichard, G A Jr;
- Pilo, A;
- Olsson, M;
- Wahren, J;
- DeFronzo, R A
Publication type:
journal article
Mechanism of improvement in glucose metabolism after chronic glyburide therapy.
Published in:
1984
By:
- Simonson, Donald C.;
- Ferrannini, Eleuterio;
- Bevilacqua, Stefano;
- Smith, Douglas;
- Barrett, Eugene;
- Carlson, Rodney;
- DeFronzo, Ralph A.;
- Simonson, D C;
- Ferrannini, E;
- Bevilacqua, S;
- Smith, D;
- Barrett, E;
- Carlson, R;
- DeFronzo, R A
Publication type:
journal article
Impairment of insulin-mediated glucose metabolism by hyperosmolality in man.
Published in:
1983
By:
- Bratusch-Marrain, Paul R.;
- DeFronzo, Ralph A.;
- Bratusch-Marrain, P R;
- DeFronzo, R A
Publication type:
journal article
Splanchnic and peripheral disposal of oral glucose in man.
Published in:
1983
By:
- Katz, Lee D.;
- Glickman, Morton G.;
- Rapoport, Stanley;
- Ferrannini, Eleuterio;
- DeFronzo, Ralph A.;
- Katz, L D;
- Glickman, M G;
- Rapoport, S;
- Ferrannini, E;
- DeFronzo, R A
Publication type:
journal article
Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man.
Published in:
1983
By:
- DeFronzo, Ralph A.;
- Ferrannini, Eleuterio;
- Hendler, Rosa;
- Felig, Philip;
- Wahren, John;
- DeFronzo, R A;
- Ferrannini, E;
- Hendler, R;
- Felig, P;
- Wahren, J
Publication type:
journal article
Increased peripheral insulin sensitivity and muscle mitochondrial enzymes but unchanged blood glucose control in type I diabetics after physical training.
Published in:
1982
By:
- Wallberg-Henriksson, H.;
- Gunnarsson, R.;
- Henriksson, J.;
- Defronzo, R.;
- Felig, P.;
- Östman, J.;
- Wahren, John;
- Ostman, J;
- Wahren, J
Publication type:
journal article
The effect of graded doses of insulin on total glucose uptake, glucose oxidation, and glucose storage in man.
Published in:
1982
By:
- Thiebaud, Daniel;
- Jacot, Eric;
- DeFronzo, Ralph A.;
- Maeder, Evelyne;
- Jequier, Eric;
- Felber, Jean-Pierre;
- Thiebaud, D;
- Jacot, E;
- DeFronzo, R A;
- Maeder, E;
- Jequier, E;
- Felber, J P
Publication type:
journal article
Insulin resistance in diabetic ketoacidosis.
Published in:
1982
By:
- Barrett, Eugene J.;
- DeFronzo, Ralph A.;
- Bevilacqua, Stefano;
- Ferrannini, Eleuterio;
- Barrett, E J;
- DeFronzo, R A;
- Bevilacqua, S;
- Ferrannini, E
Publication type:
journal article
Insulin resistance is a prominent feature of insulin-dependent diabetes.
Published in:
1982
By:
- DeFronzo, Ralph A.;
- Hendler, Rosa;
- Simonson, Donald;
- DeFronzo, R A;
- Hendler, R;
- Simonson, D
Publication type:
journal article

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