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- Title
Long-term metformin use reduces gastric cancer risk in type 2 diabetics without insulin treatment: a nationwide cohort study.
- Authors
Kim, Y.‐I.; Kim, S. Y.; Cho, S.‐J.; Park, J.‐H.; Choi, I. J.; Lee, Y. J.; Lee, E. K.; Kook, M.‐C.; Kim, C. G.; Ryu, K. W.; Kim, Y.‐W.
- Abstract
Background Metformin use has been associated with a decreased incidence and mortality of various cancers. Aim To evaluate the association between metformin use and gastric cancer. Methods We randomly selected 100 000 type 2 diabetic patients from the 2004 Korean National Health Insurance claim database, and assessed gastric cancer incidence among 39 989 patients (aged 30-97 years) who were regularly treated with anti-diabetic drugs and followed-up from 2004 to 2010. In total, 26 690 patients had used metformin out of 32 978 diabetics who had not regularly used insulin (insulin non-users), and 5855 patients had used metformin out of 7011 regular insulin users. Results Patients who used metformin showed a lower incidence of gastric cancer than those who did not use metformin, in insulin non-users ( P = 0.047, log-rank test). However, in patients on regular insulin, there was no difference of gastric cancer incidence according to metformin use. In insulin non-users, the adjusted hazard ratio ( AHR) for metformin use was 0.73 (95% confidential interval [ CI], 0.53-1.01) with borderline statistical significance ( P = 0.059). Duration of metformin use was associated with the reduction in gastric cancer risk ( AHR, 0.88; 95% CI 0.81-0.96, P = 0.003), especially in patients who used metformin for more than 3 years ( AHR, 0.57; 95% CI, 0.37-0.87; P = 0.009). Conclusion Metformin use >3 years in type 2 diabetics who do not use insulin is associated with a significantly reduced gastric cancer risk.
- Subjects
METFORMIN; STOMACH cancer treatment; PEOPLE with diabetes; INSULIN; CELL proliferation
- Publication
Alimentary Pharmacology & Therapeutics, 2014, Vol 39, Issue 8, p854
- ISSN
0269-2813
- Publication type
Article
- DOI
10.1111/apt.12660