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- Title
Two-year dynamic functional network connectivity in clinically isolated syndrome.
- Authors
Rocca, Maria A; Hidalgo de La Cruz, Milagros; Valsasina, Paola; Mesaros, Sarlota; Martinovic, Vanja; Ivanovic, Jovana; Drulovic, Jelena; Filippi, Massimo
- Abstract
Background: The features of functional network connectivity reorganization at the earliest stages of MS have not been investigated yet. Objective: To combine static and dynamic analysis of resting state (RS) functional connectivity (FC) to identify mechanisms of clinical dysfunction and recovery occurring in clinically isolated syndrome (CIS) patients. Methods: RS functional magnetic resonance imaging (fMRI) and clinical data were prospectively acquired from 50 CIS patients and 13 healthy controls (HC) at baseline, month 12 and month 24. Between-group differences and longitudinal evolution of network FC were analysed across 41 functionally relevant networks. Results: At follow-up, 47 patients developed MS. Disability remained stable (and relatively low). CIS and HC exhibited two recurring RS FC states (states 1 and 2, showing low and high internetwork connectivity, respectively). At baseline, patients showed reduced state 2 connectivity strength in the default-mode and cerebellar networks, and no differences in global dynamism versus HC. A selective FC reduction in networks affected by the clinical attack was also detected. At follow-up, increased state 2 connectivity strength and global connectivity dynamism was observed in patients versus HC. Conclusion: Longitudinal FC modifications occurring relatively early in the course of multiple sclerosis may represent a protective mechanism contributing to preserve clinical function over time.
- Subjects
FUNCTIONAL connectivity; FUNCTIONAL magnetic resonance imaging
- Publication
Multiple Sclerosis Journal, 2020, Vol 26, Issue 6, p645
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/1352458519837704