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- Title
Local skin gene expression reflects both local and systemic skin disease in patients with systemic sclerosis.
- Authors
Rice, Lisa M.; Stifano, Giuseppina; Ziemek, Jessica; Lafyatis, Robert
- Abstract
The article discusses a study that analyzed the purified ribonucleic acid (RNA) from dorsal mid-forearm skin biopsy specimens from systemic sclerosis (SSc) patients and healthy controls. Topics covered include local gene expression's relationship with local skin score vs systemic assessment of the skin or modified Rodnan skin score (mRSS), molecular quantification of local forearm skin disease, transforming growth factor (TGF)-ß-associated genes, and macrophage-associated genes.
- Subjects
BIOMARKERS; BIOPSY; STATISTICAL correlation; FOREARM; GENE expression; SKIN diseases; SYSTEMIC scleroderma; SEVERITY of illness index; DESCRIPTIVE statistics
- Publication
Rheumatology, 2016, Vol 55, Issue 2, p377
- ISSN
1462-0324
- Publication type
Article
- DOI
10.1093/rheumatology/kev335