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- Title
Sex differences in global metabolomic profiles of COVID-19 patients.
- Authors
Escarcega, Rocio Diaz; Honarpisheh, Pedram; Colpo, Gabriela Delevati; Ahnstedt, Hilda W.; Couture, Lucy; Juneja, Shivanki; Torres, Glenda; Ortiz, Guadalupe J.; Sollome, James; Tabor, Natalie; Ganesh, Bhanu P.; Choi, H. Alex; Liu, Fudong; McCullough, Louise D.; Tsvetkov, Andrey S.
- Abstract
Coronavirus disease (COVID-19), caused by SARS-CoV-2, leads to symptoms ranging from asymptomatic disease to death. Although males are more susceptible to severe symptoms and higher mortality due to COVID-19, patient sex has rarely been examined. Sex-associated metabolic changes may implicate novel biomarkers and therapeutic targets to treat COVID-19. Here, using serum samples, we performed global metabolomic analyses of uninfected and SARS-CoV-2-positive male and female patients with severe COVID-19. Key metabolic pathways that demonstrated robust sex differences in COVID-19 groups, but not in controls, involved lipid metabolism, pentose pathway, bile acid metabolism, and microbiome-related metabolism of aromatic amino acids, including tryptophan and tyrosine. Unsupervised statistical analysis showed a profound sexual dimorphism in correlations between patient-specific clinical parameters and their global metabolic profiles. Identification of sex-specific metabolic changes in severe COVID-19 patients is an important knowledge source for researchers striving for development of potential sex-associated biomarkers and druggable targets for COVID-19 patients.
- Publication
Cell Death & Disease, 2022, Vol 13, Issue 5, p1
- ISSN
2041-4889
- Publication type
Article
- DOI
10.1038/s41419-022-04861-2