We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Highly Soluble β-Glucan Fiber Modulates Mechanisms of Blood Glucose Regulation and Intestinal Permeability.
- Authors
Marcobal, Angela M.; McConnell, Bruce R.; Drexler, Riley A.; Ng, Katharine M.; Maldonado-Gomez, Maria X.; Conner, Alexandria M. S.; Vierra, Cory G.; Krishnakumar, Nithya; Gerber, Hannah M.; Garcia, Jada K. A.; Cerney, James P.; Amicucci, Matthew J.
- Abstract
β-glucans found in cereal grains have been previously demonstrated to improve blood glucose control; however, current understanding points to their high viscosity as the primary mechanism of action. In this work, we present a novel, highly soluble, low-viscosity β-glucan fiber (HS-BG fiber) and a preclinical dataset that demonstrates its impact on two mechanisms related to the prevention of hyperglycemia. Our results show that HS-BG inhibits the activity of two key proteins involved in glucose metabolism, the α-glucosidase enzyme and the SGLT1 transporter, thereby having the potential to slow starch digestion and subsequent glucose uptake. Furthermore, we demonstrate in a multi-donor fecal fermentation model that HS-BG is metabolized by several different members of the gut microbiome, producing high amounts of short-chain fatty acids (SCFAs), known agonists of GPR43 receptors in the gut related to GLP-1 secretion. The production of SCFAs was verified in the translational gut model, SHIME®. Moreover, HS-BG fiber fermentation produces compounds that restored permeability in disrupted epithelial cells, decreased inflammatory chemokines (CXCL10, MCP-1, and IL-8), and increased anti-inflammatory marker (IL-10), which could improve insulin resistance. Together, these data suggest that the novel HS-BG fiber is a promising new functional ingredient that can be used to modulate postprandial glycemic responses while the high solubility and low viscosity enable easy formulation in both beverage and solid food matrices.
- Subjects
HYPERGLYCEMIA prevention; EPITHELIAL cells; CHEMOKINES; SHORT-chain fatty acids; RESEARCH funding; BLOOD viscosity; FECES; INTESTINAL mucosa; GUT microbiome; INTESTINAL barrier function; BLOOD sugar; PERMEABILITY; GLUCOSE metabolism disorders; FERMENTATION; INSULIN resistance; DIETARY fiber; BETA-glucans; GLYCOSIDASES; OLIGOSACCHARIDES; CHEMICAL inhibitors
- Publication
Nutrients, 2024, Vol 16, Issue 14, p2240
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16142240