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- Title
Atractylodes macrocephala Koidz Alleviates Symptoms in Zymosan-Induced Irritable Bowel Syndrome Mouse Model through TRPV1, NaV1.5, and NaV1.7 Channel Modulation.
- Authors
Choi, Na-Ri; Choi, Woo-Gyun; Lee, Jong-Hwan; Park, Joon; Kim, Yun-Tai; Das, Raju; Woo, Joo-Han; Kim, Byung-Joo
- Abstract
(1) Background: Irritable bowel syndrome (IBS) is a common disease in the gastrointestinal (GI) tract. Atractylodes macrocephala Koidz (AMK) is known as one of the traditional medicines that shows a good efficacy in the GI tract. (2) Methods: We investigated the effect of AMK in a network pharmacology and zymosan-induced IBS animal model. In addition, we performed electrophysiological experiments to confirm the regulatory mechanisms related to IBS. (3) Results: Various characteristics of AMK were investigated using TCMSP data and various analysis systems. AMK restored the macroscopic changes and weight to normal. Colonic mucosa and inflammatory factors were reduced. These effects were similar to those of amitriptyline and sulfasalazine. In addition, transient receptor potential (TRP) V1, voltage-gated Na+ (NaV) 1.5, and NaV1.7 channels were inhibited. (4) Conclusion: These results suggest that AMK may be a promising therapeutic candidate for IBS management through the regulation of ion channels.
- Subjects
INFLAMMATION prevention; ANTI-inflammatory agents; CHINESE medicine; MEMBRANE transport proteins; BIOLOGICAL models; IRRITABLE colon; INTESTINAL mucosa; RESEARCH funding; PHARMACEUTICAL chemistry; CALCIUM channels; DISEASE management; PLANT roots; GASTROINTESTINAL system; TREATMENT effectiveness; ALLERGIES; MICE; AMITRIPTYLINE; MEDICINAL plants; GLUCANS; DRUG efficacy; ANIMAL experimentation; MOLECULAR structure; SULFONAMIDES; QUALITY of life; CAPSAICIN; ION channels; GASTROINTESTINAL diseases; SYMPTOMS
- Publication
Nutrients, 2024, Vol 16, Issue 11, p1683
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16111683