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- Title
Walnut Oligopeptide Delayed Improved Aging-Related Learning and Memory Impairment in SAMP8 Mice.
- Authors
Du, Qian; Xu, Meihong; Wu, Lan; Fan, Rui; Hao, Yuntao; Liu, Xinran; Mao, Ruixue; Liu, Rui; Li, Yong
- Abstract
Aging-related learning and memory decline are hallmarks of aging and pose a significant health burden. The effects of walnut oligopeptides (WOPs) on learning and memory were evaluated in this study. Sixty SAMP8 mice were randomly divided into four groups (15 mice/group), including one SAMP8 age-control group and three WOP-treated groups. SAMR1 mice (n = 15) that show a normal senescence rate were used as controls. The SAMP8 and SAMR1 controls were administered ordinary sterilized water, while the WOP-intervention groups were administered 110, 220, and 440 mg/kg·bw of WOPs in water, respectively. The whole intervention period was six months. The remaining 15 SAMP8 (4-month-old) mice were used as the young control group. The results showed that WOPs significantly improved the decline in aging-related learning/memory ability. WOPs significantly increased the expression of BDNF and PSD95 and decreased the level of APP and Aβ1-42 in the brain. The mechanism of action may be related to an increase in the activity of antioxidant enzymes (SOD and GSH-Px), a reduction in the expression of inflammatory factors (TNF-α and IL-1β) in the brain and a reduction in oxidative stress injury (MDA). Furthermore, the expression of AMPK, SIRT-1, and PGC-1α was upregulated and the mitochondrial DNA content was increased in brain. These results indicated that WOPs improved aging-related learning and memory impairment. WOP supplementation may be a potential and effective method for the elderly.
- Subjects
BRAIN; NERVE tissue proteins; DNA; WALNUT; OLIGOPEPTIDES; ANIMAL experimentation; ANTIOXIDANTS; INTERLEUKIN-1; GENE expression; OXIDATIVE stress; MITOCHONDRIA; DIETARY supplements; TREATMENT effectiveness; AGING; LEARNING disabilities; MEMORY disorders; TUMOR necrosis factors; BRAIN-derived neurotrophic factor; MICE; EVALUATION
- Publication
Nutrients, 2022, Vol 14, Issue 23, p5059
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14235059