We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Comparison of the Concordance of Cardiometabolic Diseases and Physical and Laboratory Examination Findings between Monozygotic and Dizygotic Korean Adult Twins: A Cross-Sectional Study Using KoGES HTS Data.
- Authors
Kang, Ho Suk; Kim, So Young; Choi, Hyo Geun; Lim, Hyun; Kim, Joo-Hee; Kim, Ji Hee; Cho, Seong-Jin; Nam, Eun Sook; Min, Kyueng-Whan; Park, Ha Young; Kim, Nan Young; Choi, Younghee; Kwon, Mi Jung
- Abstract
This study investigated the contribution of genetic and environmental factors to cardiometabolic diseases (CMDs) by comparing disease concordance in monozygotic and dizygotic twins. This cross-sectional study analyzed 1294 (1040 monozygotic and 254 dizygotic) twin pairs (>20 years) based on the Korean Genome and Epidemiology Study data (2005–2014). The odds ratios of disease concordance were calculated using binomial and multinomial logistic regression models. The occurrence of CMDs (hypertension, hyperlipidemia, type 2 diabetes, cerebral stroke, transient ischemic attack, and ischemic heart disease) and related physical and laboratory levels did not differ between the monozygotic and dizygotic twin groups. The odds for concordance of the presence/absence of CMDs and the likelihood of incident CMD within monozygotic twins were comparable to that of dizygotic twins. The absolute differences in hemoglobin A1c, insulin, low- and high-density lipoprotein cholesterol, total cholesterol, triglycerides, and systolic blood pressure were lower in monozygotic twins than in dizygotic twins. Absolute differences in fasting glucose and diastolic blood pressure did not differ between groups. Although baseline levels of several laboratory parameters related to CMD showed a strong likelihood of heritability in monozygotic twins, CMD phenotype appears to be largely affected by environmental factors.
- Subjects
SOUTH Korea; CARDIOVASCULAR diseases risk factors; PHYSICAL diagnosis; CLINICAL pathology; HYPERTENSION; HDL cholesterol; GENETICS; TRANSIENT ischemic attack; CROSS-sectional method; ISCHEMIC stroke; MYOCARDIAL ischemia; CARDIOVASCULAR diseases; MONOZYGOTIC twins; LDL cholesterol; ENVIRONMENTAL health; RISK assessment; COMPARATIVE studies; HYPERLIPIDEMIA; TYPE 2 diabetes; DESCRIPTIVE statistics; ODDS ratio; LOGISTIC regression analysis; EPIDEMIOLOGICAL research
- Publication
Nutrients, 2022, Vol 14, Issue 22, p4834
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14224834