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- Title
A Randomised, Double-Blind, Placebo-Controlled Crossover Trial of Resveratrol Supplementation for Prophylaxis of Hormonal Migraine.
- Authors
Dzator, Jemima S. A.; Howe, Peter R. C.; Coupland, Kirsten G.; Wong, Rachel H. X.
- Abstract
Resveratrol, a vasoactive phytoestrogen, has beneficial effects on cerebrovascular function. Previous research has shown that hormonal migraineurs have poorer cerebrovascular function than non-migraineur women. We aimed to investigate if resveratrol supplementation for three months could reduce the hormonal migraine burden index (HMBI: the number of days with menstrual migraine per month), reduce migraine-related disability and improve migraine-related quality of life. A randomised, double-blind, placebo-controlled, crossover, intervention trial was conducted in 62 hormonal migraineurs (mean age: 37.5 ± 0.8 years). Participants consumed 75 mg of resveratrol or matching placebo capsules twice daily for three months before crossing over to the other treatment arm. Participants completed a daily diary and the Headache Impact Test-6™, Migraine Disability Assessment and Migraine-Specific Quality of Life questionnaires at months 0, 3 and 6. The HMBI was the primary outcome and was calculated using data extracted from the participant's diary. No differences in the HMBI (p = 0.895), the Headache Impact Test-6™, the Migraine Disability Assessment and Migraine-Specific Quality of Life were found between the resveratrol and placebo treatments. Resveratrol supplementation for three months did not affect the HMBI, the migraine-related disability or quality of life measures in our cohort of hormonal migraineurs.
- Subjects
MIGRAINE prevention; MIGRAINE; MENSTRUAL cycle; RESVERATROL; DIETARY supplements; TREATMENT effectiveness; RANDOMIZED controlled trials; COMPARATIVE studies; PRE-tests &; post-tests; PLACEBOS; BLIND experiment; QUALITY of life; DESCRIPTIVE statistics; QUESTIONNAIRES; STATISTICAL sampling; CROSSOVER trials; EVALUATION
- Publication
Nutrients, 2022, Vol 14, Issue 9, p1763
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14091763