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- Title
Improvement in Uncontrolled Eating Behavior after Laparoscopic Sleeve Gastrectomy Is Associated with Alterations in the Brain–Gut–Microbiome Axis in Obese Women.
- Authors
Dong, Tien S.; Gupta, Arpana; Jacobs, Jonathan P.; Lagishetty, Venu; Gallagher, Elizabeth; Bhatt, Ravi R.; Vora, Priten; Osadchiy, Vadim; Stains, Jean; Balioukova, Anna; Chen, Yijun; Dutson, Erik; Mayer, Emeran A.; Sanmiguel, Claudia
- Abstract
Background: Bariatric surgery is proven to change eating behavior and cause sustained weight loss, yet the exact mechanisms underlying these changes are not clearly understood. We explore this in a novel way by examining how bariatric surgery affects the brain–gut–microbiome (BGM) axis. Methods: Patient demographics, serum, stool, eating behavior questionnaires, and brain magnetic resonance imaging (MRI) were collected before and 6 months after laparoscopic sleeve gastrectomy (LSG). Differences in eating behavior and brain morphology and resting-state functional connectivity in core reward regions were correlated with serum metabolite and 16S microbiome data. Results: LSG resulted in significant weight loss and improvement in maladaptive eating behaviors as measured by the Yale Food Addiction Scale (YFAS). Brain imaging showed a significant increase in brain volume of the putamen (p.adj < 0.05) and amygdala (p.adj < 0.05) after surgery. Resting-state connectivity between the precuneus and the putamen was significantly reduced after LSG (p.adj = 0.046). This change was associated with YFAS symptom count. Bacteroides, Ruminococcus, and Holdemanella were associated with reduced connectivity between these areas. Metabolomic profiles showed a positive correlation between this brain connection and a phosphatidylcholine metabolite. Conclusion: Bariatric surgery modulates brain networks that affect eating behavior, potentially through effects on the gut microbiota and its metabolites.
- Subjects
AMYGDALOID body physiology; LECITHIN metabolism; BASAL ganglia; HUMAN microbiota; FOOD habits; GASTRECTOMY; LAPAROSCOPIC surgery; MAGNETIC resonance imaging; OBESITY; BARIATRIC surgery; OVERWEIGHT persons; PARIETAL lobe; PATIENTS; QUESTIONNAIRES; SURGERY; WOMEN'S health; DESCRIPTIVE statistics; REHABILITATION
- Publication
Nutrients, 2020, Vol 12, Issue 10, p2924
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12102924