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- Title
USPIO enhanced lymph node MRI using 3D multi-echo GRE in a rabbit model.
- Authors
Kim, Sung Hun; Oh, Soon Nam; Choi, Hyun Seok; Lee, Hyun Sil; Jun, Jaeseop; Nam, Yoonho; Lee, Sung Hak; Lee, Jin-Kwon; Lee, Hae Giu
- Abstract
Ultrasmallsuperparamagnetic iron oxide (USPIO) has been suggested to be a negative MR contrast agent to detect metastatic lymph nodes. Previously reported studies have evaluated the diagnostic performance of USPIO-enhanced MR lymph node imaging based on signal intensity. In this study, we investigate the specific performance of three different parametric approaches (normalized signal intensity, R2* and susceptibility) using 3D multi-echo gradient echo to quantify the USPIO particles in lymph nodes. Nine rabbits with VX2 tumor implants were scanned before and after USPIO injection. From 3D multi-echo GRE magnitude and phase data, we generated multi-echo combined T2*-weighted images, an R2* map, and a quantitative susceptibility map. Eighteen lymph nodes (nine reactive and nine metastatic) were evaluated and showed remarkable signal drops in the area of USPIO accumulation. On parametric analysis, the R2* difference before and after USPIO injection was significantly different ( p < 0.05) between reactive and metastatic lymph nodes; in contrast, the normalized signal intensity and susceptibility were not significantly different between the nodes. Our study showed the potential utility of USPIO-enhanced MRI using R2* mapping from 3D multi-echo GRE for the detection of lymph node metastasis and parametric analysis of lymph node status in a rabbit model. Copyright © 2016 John Wiley & Sons, Ltd.
- Publication
Contrast Media & Molecular Imaging, 2016, Vol 11, Issue 6, p544
- ISSN
1555-4309
- Publication type
Article
- DOI
10.1002/cmmi.1716