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- Title
Efficacy and Safety of Pyridoxal 5'-Phosphate (MC-1) in High-Risk Patients Undergoing Coronary Artery Bypass Graft Surgery.
- Authors
Alexander, John H.; Emery Jr, Robert W.; Carrier, Michel; Ellis, Stephen J.; Mehta, Rajendra H.; Hasselblad, Vic; Menasche, Philippe; Khalil, Ahmad; Cote, Robert; Bennett-Guerrero, Elliot; Mack, Michael J.; Schuler, Gerhard; Harrington, Robert A.; Tardif, Jean-Claude
- Abstract
The article focuses on a study testing the effectiveness and safety of the naturally occurring pyridoxine metabolite and purinergic receptor antagonist MC-1 given to patients undergoing coronary artery bypass graft (CABG) surgery. The objective of the trial was to reduce morbidity and mortality rates in CABG patients due to common complications related to ischemia-reperfusion injury and myocardial infarction (MI). Researchers concluded that MC-1 did not reduce cardiovascular death or nonfatal MI among intermediate to high-risk patients undergoing CABG surgery.
- Subjects
CORONARY artery bypass risk factors; SURGICAL complications; MYOCARDIAL revascularization; REPERFUSION injury; ISCHEMIA; MORTALITY; METABOLITES; PATIENTS
- Publication
JAMA: Journal of the American Medical Association, 2008, Vol 299, Issue 15, p1777
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.299.15.joc80027