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- Title
P172 - PROTEIN OXIDATION IN HYPERTENSIVE PATIENTS, VITAMIN C AND E LEVELS AND ANTIOXIDANT DEFENSE MECHANISM.
- Authors
KORKMAZ, Gülcan GÜNTAŞ; BAVUNOĞLU, Işıl; GENÇ, Habibe; BALCI, Huriye; KALENDER, Betül; GELISGEN, Remise; KARTER, Yesari; ŞIMŞEK, Gönül; UZUN, Hafize
- Abstract
Aim: Our aim is to evaluate serum protein hydroperoxides (P-OOH), advanced oxidation protein products (AOPP), vitamin E and C and total antioxidant capacity (TAC) levels in essential (EH), white coat (WCH) and renal (RH) hypertensive patients and compare with normotensive (NT) volunteers. Materials and Methods: 22 EH (F/M:12/10) between the ages of 52+/-10, 22 WCH (F/M:12/10) between the ages of 51+/-10, 22 RH (F/M:13/9) between the ages of 55+/-11 and 22 NT (F/M:11/10) between the ages of 49+/-8 were chosen as a volunteer for the research whose blood pressure > 140/90. Results: EH and RH groups exhibited higher P-OOH, AOPP (p <0.001 for both) and lower vitamin C levels (p <0.001 for both) than WCH and NT. There was no significant difference between the P-OOH, AOPP and vitamin C levels of WCH and NT. Plasma vitamin E and TAC levels were significantly decreased in EH (p <0.001 for both), RH (p <0.001 for both), WCH (p <0.01, p <0.05, respectively), as compared with NT. Conclusion: Increased levels of protein oxidation and reduced vitamin E, vitamin C and TAC clearly demonstrate the presence of oxidative stress in hypertension. Our data also indicate that, WCH represent an intermediate group between NT and HT when endothelial dysfunction is concerned. Vitamin E and C may be an important treatment modality in the treatment of hypertension. While this contributes to the relevant information about the pathogenesis and prognosis of hypertension in the oxidation of protein, it also indicates the need for new studies on the subject
- Subjects
HYDROPEROXIDES; ANTIOXIDANTS; VITAMIN E
- Publication
Turkish Journal of Biochemistry / Turk Biyokimya Dergisi, 2012, Vol 37, Issue S1, p313
- ISSN
0250-4685
- Publication type
Abstract