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- Title
Cu<sup>II</sup>-Promoted Aerobic Cascade Reactions of 2-Alkynylanilines with Methyl Perfluoroalk-2-ynoates: En Route to 4-Carbonyl-2-perfluoroalkylquinolines.
- Authors
Han, Jing; Shen, Yangyong; Sun, Xuechun; Yao, Qiuxia; Chen, Jie; Deng, Hongmei; Shao, Min; Fan, Bozhen; Zhang, Hui; Cao, Weiguo
- Abstract
Using air as the oxygen source, 4-carbonyl-2-perfluoroalkylquinolines were prepared in good to excellent yields, from readily available 2-alkynylanilines and methyl perfluoroalk-2-ynoates through a CuII-promoted sequential process that omits the isolation of the enamine intermediates. The reaction tolerates several useful functionalities including ether, ester and chloro substituents.
- Subjects
ANILINE synthesis; CHEMICAL reactions; SUBSTITUENTS (Chemistry); ENAMINES; FLUORINE compounds synthesis; ORGANIC synthesis research; CHEMICAL synthesis
- Publication
European Journal of Organic Chemistry, 2015, Vol 2015, Issue 9, p2061
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201403633