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- Title
RET gene mutations are not a common cause of congenital solitary functioning kidney in adults.
- Authors
Oram, Richard A.; Edghill, Emma L.; Woolf, Adrian S.; Hennekam, R. C.; Ellard, Sian; Hattersley, A. T.; Bingham, Coralie
- Abstract
The article discusses a study that examined the causes of solitary functioning kidney. In human beings, unilateral renal agenesis manifests in approximately 0.01 percent births, resulting in a solitary functioning kidney, while bilateral renal agenesis and/or severe dysplasia happens in a similar frequency but usually leads to neonatal mortality. The study suggested that rearranged during transfection (RET) mutations give rise to renal failure that causes postnatal deaths.
- Subjects
POTTER'S syndrome; KIDNEY diseases; DYSPLASIA; NEONATAL mortality; GENE transfection
- Publication
NDT Plus, 2009, Vol 2, Issue 2, p183
- ISSN
1753-0784
- Publication type
Article
- DOI
10.1093/ndtplus/sfn204