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- Title
Impairment Mechanisms and Intervention Approaches for Aged Human Neuromuscular Junctions.
- Authors
Badawi, Yomna; Nishimune, Hiroshi
- Abstract
The neuromuscular junction (NMJ) is a chemical synapse formed between a presynaptic motor neuron and a postsynaptic muscle cell. NMJs in most vertebrate species share many essential features; however, some differences distinguish human NMJs from others. This review will describe the pre- and postsynaptic structures of human NMJs and compare them to NMJs of laboratory animals. We will focus on age-dependent declines in function and changes in the structure of human NMJs. Furthermore, we will describe insights into the aging process revealed from mouse models of accelerated aging. In addition, we will compare aging phenotypes to other human pathologies that cause impairments of pre- and postsynaptic structures at NMJs. Finally, we will discuss potential intervention approaches for attenuating age-related NMJ dysfunction and sarcopenia in humans.
- Subjects
MYONEURAL junction; MOTOR neurons; MUSCLE cells; LABORATORY animals; OLDER people
- Publication
Frontiers in Molecular Neuroscience, 2020, Vol 13, pN.PAG
- ISSN
1662-5099
- Publication type
Article
- DOI
10.3389/fnmol.2020.568426