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- Title
Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model.
- Authors
Liang, T Jake; Law, John L M; Pietschmann, Thomas; Ray, Stuart C; Bukh, Jens; Bull, Rowena; Chung, Raymond T; Tyrrell, D Lorne; Houghton, Michael; Rice, Charles M
- Abstract
For any controlled human infection model (CHIM), a safe, standardized, and biologically relevant challenge inoculum is necessary. For hepatitis C virus (HCV) CHIM, we propose that human-derived high-titer inocula of several viral genotypes with extensive virologic, serologic, and molecular characterizations should be the most appropriate approach. These inocula should first be tested in human volunteers in a step-wise manner to ensure safety, reproducibility, and curability prior to using them for testing the efficacy of candidate vaccines.
- Subjects
PREVENTION of infectious disease transmission; VIRUS disease drug therapy; HEPATITIS C prevention; BIOLOGICAL models; RESEARCH evaluation; VIRAL vaccines; VIRAL load; HEPATITIS C; HEPATITIS viruses; INFECTION; GENOTYPES; RNA viruses; MEDICAL research
- Publication
Clinical Infectious Diseases, 2023, Vol 77, pS257
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciad336