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- Title
Durability of Immune Responses After Boosting in Ad26.COV2.S-Primed Healthcare Workers.
- Authors
Sablerolles, Roos S G; Rietdijk, Wim J R; Goorhuis, Abraham; Postma, Douwe F; Visser, Leo G; Schmitz, Katharina S; Geers, Daryl; Bogers, Susanne; Haren, Eva van; Koopmans, Marion P G; Dalm, Virgil A S H; Kootstra, Neeltje A; Huckriede, Anke L W; Akkerman, Renate; Beukema, Martin; Lafeber, Melvin; Baarle, Debbie van; Vries, Rory D de; Kuy, P Hugo M van der; GeurtsvanKessel, Corine H
- Abstract
The emergence of SARS-CoV-2 variants raised questions regarding the durability of immune responses after homologous or heterologous boosters after Ad26.COV2.S-priming. We found that SARS-CoV-2–specific binding antibodies, neutralizing antibodies, and T cells are detectable 5 months after boosting, although waning of antibodies and limited cross-reactivity with Omicron BA.1 was observed.
- Subjects
COVID-19; IMMUNOGLOBULINS; COVID-19 vaccines; TIME; IMMUNE system; RESEARCH funding; DRUG allergy
- Publication
Clinical Infectious Diseases, 2023, Vol 76, Issue 3, pe533
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciac495