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- Title
Pruritic urticarial papules and plaques of pregnancy (PUPPP): a clinicopathological review of 35 patients.
- Authors
Powell, Frank C.; Dervan, Peter; Wayte, Jeffrey; O'Loughlin, Sean
- Abstract
The clinical features of 35 cases of Pruritic Urticarial Papules and Plaques of Pregnancy (PUPPP) seen over an 8 year period were reviewed with regard to age and gestational stage of onset, evolution and severity of disease and response to therapy. The histologic features in biopsies from 15 patients were analysed for pattern and extent of inflammatory change and the composition of the inflammatory cells were studied with a panel of monoclonal antibodies. This study confirmed PUPPP to be a well defined clinical entity mainly occurring in young primagravidas in the third trimester and usually responsive to topical treatments. Histologically, perivascular upper and mid-dermal inflammatory changes were pre- sent in all biopsies with epidermal spongiosis and vesiculation a prominant feature in many cases. The inflammatory infiltrate was composed of an admixture of T lymphocytes and macrophages.
- Subjects
MONOCLONAL antibodies; MOLECULAR cloning; PREGNANCY; HISTOPATHOLOGY; IMMUNOGLOBULINS; MOLECULAR genetics; GENETIC engineering
- Publication
Journal of the European Academy of Dermatology & Venereology, 1996, Vol 6, Issue 2, p105
- ISSN
0926-9959
- Publication type
Article
- DOI
10.1111/j.1468-3083.1996.tb00153.x