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- Title
Central angiotensin II-induced Alzheimer-like tau phosphorylation in normal rat brains
- Authors
Tian, Minjie; Zhu, Donglin; Xie, Wei; Shi, Jingping
- Abstract
Abstract: Growing evidence suggests that Alzheimer disease (AD) origins in vascular lesions. As the crucial mediator of vascular pathology, angiotensin II-induced significant amyloid production in our laboratory, although amyloid neurotoxicity depended on phosphorylated tau (p-tau) in recent studies. In the present study, p-tau levels were significantly elevated by central angiotensin II via glycogen synthase kinase 3β (GSK 3β) and other tau kinases. Moreover, angiotensin II-induced cognitive impairment and tau phosphorylation was attenuated by losartan and a GSK 3β inhibitor. These findings implicate Ang II as a crucial mediator of AD pathology and a link between cardiovascular events and AD.
- Subjects
ANGIOTENSIN II; ALZHEIMER'S disease; TAU proteins; PHOSPHORYLATION; LABORATORY rats; BRAIN physiology
- Publication
FEBS Letters, 2012, Vol 586, Issue 20, p3737
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2012.09.004