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- Title
Dose escalation of Stereotactic Body Radiotherapy (SBRT) for locally advanced unresectable pancreatic cancer patients with CyberKnife: protocol of a phase I study.
- Authors
Shui-Wang Qing; Xiao-Ping Ju; Yang-Sen Cao; Huo-Jun Zhang; Qing, Shui-Wang; Ju, Xiao-Ping; Cao, Yang-Sen; Zhang, Huo-Jun
- Abstract
<bold>Background: </bold>Dose escalation of SBRT for locally advanced pancreatic cancer patients had been reported in several studies in one or three fractions, and phase I protocol was developed to investigate the maximum tolerated dose with CyberKnife for locally advanced unresectable pancreatic cancer patients in five fractions.<bold>Methods: </bold>The study is designed as a mono-center phase I study. The primary endpoint is to determine the maximum tolerated dose by frequency of III/IV GI (gastrointestinal) toxicity. Adverse events (AE) according to Common Toxicity Criteria (CTC) version 4. Doses of 7 Gy, 7.5 Gy, 8 Gy, 8.5 Gy, 9 Gy, 9.5Gy x 5 respectively would be delivered while meeting with normal tissue constraints. A minimum of three patients will be included for each dosage level. And an interval is 4 weeks from the first patient treatment to the next patient treatment at each dose level. The maximal tolerated dose will be defined as the dose for which at least two patients in three, or at least three patients in nine, will present with a limiting toxicity.<bold>Discussion: </bold>Since the dose and fractions of SBRT treatment for locally advanced pancreatic cancer patients are still unknown, we propose to conduct a Phase I study determining the maximum tolerated dose of CyberKnife SBRT for the treatment of locally advanced pancreatic tumor based on a 5 fractions treatment regimen. This trial protocol has been approved by the Ethics committee of Changhai hospital. The ethics number is 2016-030-01.<bold>Trial Registration: </bold>Clinical trials number: NCT02716207 . Date of registration: 20 March 2016.
- Subjects
RADIOTHERAPY; CANCER patients; PANCREATIC cancer; RADIATION doses; MEDICAL protocols; PANCREATIC cancer treatment; CLINICAL trials; COMPARATIVE studies; DRUG dosage; DRUG toxicity; EXPERIMENTAL design; RESEARCH methodology; MEDICAL cooperation; PANCREATIC tumors; RADIOSURGERY; RESEARCH; EVALUATION research
- Publication
Radiation Oncology, 2017, Vol 12, p1
- ISSN
1748-717X
- Publication type
journal article
- DOI
10.1186/s13014-016-0760-1