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- Title
From axon-glial signalling to myelination: the integrating role of oligodendroglial Fyn kinase.
- Authors
Krämer-Albers, Eva-Maria; White, Robin
- Abstract
Central nervous system myelination requires recognition and signalling processes between neuronal axons and oligodendrocytes. Complex cellular rearrangements occur in myelination-competent oligodendrocytes requiring spatio-temporal control mechanisms. Although the molecular repertoire is becoming increasingly transparent, the signalling mechanisms governing myelination initiation are only poorly understood. The non-receptor tyrosine kinase Fyn has been implicated in axon-glial signal transduction and in several cellular processes required for oligodendrocyte maturation and myelination. Here, we review oligodendroglial Fyn signalling and discuss the role of Fyn in axon-glia interaction mediating myelination.
- Subjects
MYELINATION; AXONS; NEUROGLIA; CELLULAR signal transduction; OLIGODENDROGLIA; MYELIN proteins; INTEGRINS; PROTEIN-tyrosine kinases
- Publication
Cellular & Molecular Life Sciences, 2011, Vol 68, Issue 12, p2003
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-010-0616-z