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- Title
TRAIL promotes the survival, migration and proliferation of vascular smooth muscle cells.
- Authors
P. Secchiero; C. Zerbinati; E. Rimondi; F. Corallini; D. Milani; V. Grill; G. Forti; S. Capitani; G. Zauli
- Abstract
Human and rat primary sub-cultured vascular smooth muscle cells (VSMCs) showed clear expression of the death receptors TRAIL-R1 and TRAIL-R2; however, recombinant soluble TRAIL did not induce cell death when added to these cells. TRAIL tended to protect rat VSMCs from apoptosis induced either by inflammatory cytokines tumor necrosis factor-a + interleukin-1ß + interferon-? or by prolonged serum withdrawal, and promoted a significant increase in VSMC proliferation and migration. Of note, all the biological effects induced by TRAIL were significantly inhibited by pharmacological inhibitors of the ERK pathway. Western blot analysis consistently showed that TRAIL induced a significant activation of ERK1/2, and a much weaker phosphorylation of Akt, while it did not affect the p38/MAPK pathway. Taken together, these data strengthen the notion that the TRAIL/TRAIL-R system likely plays a role in the biology of the vascular system by affecting the survival, migration and proliferation of VSMCs.
- Subjects
MUSCLE cells; INTERLEUKINS; GROWTH factors; CYTOKINES; MOLECULAR biology
- Publication
Cellular & Molecular Life Sciences, 2004, Vol 61, Issue 15, p1965
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-004-4197-6