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- Title
Distinct Roles of GABA<sub>A</sub> and GABA<sub>B</sub> Receptors in Balancing and Terminating Persistent Cortical Activity.
- Authors
Mann, Edward O.; Kohl, Michael M.; Paulsen, Ole
- Abstract
Cortical networks spontaneously fluctuate between persistently active Upstates and quiescent Downstates. The Upstates are maintained by recurrent excitation within local circuits, and can be turned on and off by synaptic input. GABAergic inhibition is believed to be important for stabilizing such persistent activity by balancing the excitation, and could have an additional role in terminating the Up state. Here, we report that GABAA and GABAB receptor-mediated inhibition have distinct and complementary roles in balancing and terminating persistent activity. In a model of Up-Downstates expressed in slices of rat entorhinal cortex, the GABAA receptor antagonist, gabazine (50 -500nM), concentration-dependently decreased Upstate duration, eventually leading to epileptiform bursts. In contrast, the GABAB receptor antagonist, CGP55845 (50 nM to 1 μM), increased the duration of persistent network activity, and prevented stimulus induced Down state transitions. These results suggest that while GABAA receptor-mediated inhibition is necessary for balancing persistent activity, activation of GABAB receptors contributes to terminating Up states.
- Subjects
HIGHER nervous activity; NEUROPLASTICITY; GABA; DRUG antagonism; RECEPTOR antibodies; GENETICS
- Publication
Journal of Neuroscience, 2009, Vol 29, Issue 23, p7513
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.6162-08.2009